Gaza’s vital Rafah crossing remained closed Wednesday after Israeli forces seized it the day before. Associated Press journalists heard sporadic explosions and gunfire in the area overnight, including two large blasts early Wednesday.

Rafah has been a vital conduit for humanitarian aid since the start of the war and is the only place where people can enter and exit. Israel now controls all of Gaza’s border crossings for the first time since it withdrew troops and settlers from the territory nearly two decades ago.

Gaza’s Health Ministry says at least 46 patients and wounded people who had been scheduled to leave Tuesday for medical treatment have been left stranded.

The Israeli military said Wednesday it has reopened the Kerem Shalom crossing into Gaza, a key terminal for the entry of humanitarian aid that was closed over the weekend after a Hamas rocket attack killed four Israeli soldiers nearby. But the United Nations agency for Palestinian refugees said no aid has yet entered and there is no one to receive it on the Palestinian side.